Collaborative development and spatial layout of industry is the core of regional development. Current domestic and international economic situation is undergoing profound changes，many enterprises are facing the risk of changes in The exchange rate of RMB，market competition is intensifying，the plight of the internal and external labor costs are high，and has formed a Forced mechanism，and discussing regional industrial Collaborative development and spatial layout is of great in this environment. There is a high degree of geo-spatial proximity on the stage of economic development in the Pearl River Delta region and has a strong similarity，at the same time. Most of the enterprises in the Pearl Ri